The abundance of deleterious polymorphisms in humans.
نویسنده
چکیده
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans.
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ورودعنوان ژورنال:
- Genetics
دوره 190 4 شماره
صفحات -
تاریخ انتشار 2012